Mutations in the primary sigma factor σA and termination factor rho that reduce susceptibility to cell wall antibiotics.

Abstract excerpt

Combinations of glycopeptides and β-lactams exert synergistic antibacterial activity, but the evolutionary mechanisms driving resistance to both antibiotics remain largely unexplored. By repeated subculturing with increasing vancomycin (VAN) and cefuroxime (CEF) concentrations, we isolated an evolved strain of the model bacterium Bacillus subtilis with reduced susceptibility to both antibiotics. Whole-genome...

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• Bacillus subtilis
• Cell Wall
• Drug Resistance, Bacterial
• Gene Expression Regulation, Bacterial
• Genome, Bacterial