Article
Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis.
Science (New York, N.Y.) - 8 Jun 2012
Iliev Iliyan D, Funari Vincent A, Taylor Kent D, Nguyen Quoclinh, Reyes Christopher N, Strom Samuel P, Brown Jordan, Becker Courtney A, Fleshner Phillip R, Dubinsky Marla, Rotter Jerome I, Wang Hanlin L, McGovern Dermot P B, Brown Gordon D, Underhill David M
Abstract excerpt
The intestinal microflora, typically equated with bacteria, influences diseases such as obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a rich fungal community that interacts with the immune system through the innate immune receptor Dectin-1. Mice lacking Dectin-1 exhibited increased susceptibility to chemically induced colitis, which was the result of altered responses to...
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