Ability of rabeprazole to prevent gastric mucosal damage from clopidogrel and low doses of aspirin depends on CYP2C19 genotype.

doi:10.1016/j.cgh.2012.04.016

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Ability of rabeprazole to prevent gastric mucosal damage from clopidogrel and low doses of aspirin depends on CYP2C19 genotype.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Aug 2012

Uotani Takahiro, Sugimoto Mitsushige, Nishino Masafumi, Kodaira Chise, Yamade Mihoko, Sahara Shu, Yamada Takanori, Osawa Satoshi, Sugimoto Ken, Tanaka Tatsuo, Umemura Kazuo, Watanabe Hiroshi, Miyajima Hiroaki, Furuta Takahisa

Abstract excerpt

BACKGROUND & AIMS: Low doses of aspirin can injure the gastric mucosa. It is not clear whether other drugs such as the antiplatelet agent clopidogrel also cause gastric mucosal injury or exacerbate aspirin-induced injury, or whether proton pump inhibitors prevent damage. METHODS: Twenty Japanese subjects with different CYP2C19 genotypes were randomly assigned to groups that were given a low dose of aspirin (100...

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PMID: 22542748
DOI: 10.1016/j.cgh.2012.04.016

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