Article
Endoscopic analysis of gastric ulcer after one week's treatment with omeprazole and rabeprazole in relation to CYP2C19 genotype.
Digestive diseases and sciences - 1 Apr 2008
Ando Takashi, Ishikawa Takeshi, Kokura Satoshi, Naito Yuji, Yoshida Norimasa, Yoshikawa Toshikazu
Abstract excerpt
In Japanese healthy CYP2C19 extensive metabolizers, rabeprazole 10 mg shows a faster onset of action and stronger inhibition of acid secretion than does omeprazole 20 mg on the first 3 days of administration. We evaluated gastric ulcer improvement after 1 week's treatment with rabeprazole or omeprazole in relation to CYP2C19 polymorphism. A 6-mm rubber disc was placed temporarily at the side of the ulcer for...
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