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Article

Prevention of gastric mucosal injury induced by anti-platelet drugs by famotidine.

Journal of clinical pharmacology - 1 Aug 2014

Uotani Takahiro, Sugimoto Mitsushige, Nishino Masafumi, Ichikawa Hitomi, Sahara Shu, Yamade Mihoko, Iwaizumi Moriya, Yamada Takanori, Osawa Satoshi, Sugimoto Ken, Umemura Kazuo, Watanabe Hiroshi, Miyajima Hiroaki, Furuta Takahisa

Abstract excerpt

Anti-platelet drug-induced gastric mucosal injury correlates with intragastric pH. Our aim was to investigate prophylaxis effects of famotidine, one of the representative histamine-2 receptor antagonists (H2RA), on gastric mucosal injury induced by dual therapy with low-dose aspirin and clopidogrel in relation to Helicobacter pylori (H. pylori) infection and CYP2C19 genotypes. This study was conducted for 20...

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Identifiers

PMID: 24615745
DOI: 10.1002/jcph.284

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