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Article

IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor α antagonist.

The Journal of allergy and clinical immunology - 1 Aug 2012

Slager Rebecca E, Otulana Babatunde A, Hawkins Gregory A, Yen Yu Ping, Peters Stephen P, Wenzel Sally E, Meyers Deborah A, Bleecker Eugene R

Abstract excerpt

BACKGROUND: This is the first large pharmacogenetic investigation of the inflammatory IL-4/IL-13 pathway in patients with moderate-to-severe asthma. We analyzed genomic DNA from participants in a 12-week placebo-controlled efficacy trial of pitrakinra (1, 3, or 10 mg twice daily), a novel IL-4/IL-13 pathway antagonist (Clinicaltrials.govNCT00801853). OBJECTIVES: The primary hypothesis for this analysis is that...

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Identifiers

PMID: 22541248
DOI: 10.1016/j.jaci.2012.03.030
PMCID: PMC3992925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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