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Article

A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Apr 2012

Ghosh Debolina, LeVault Kelsey R, Barnett Aaron J, Brewer Gregory J

Abstract excerpt

The brain depends on redox electrons from nicotinamide adenine dinucleotide (reduced form; NADH) to produce ATP and oxyradicals (reactive oxygen species [ROS]). Because ROS damage and mitochondrial dysregulation are prominent in aging and Alzheimer's disease (AD) and their relationship to the redox state is unclear, we wanted to know whether an oxidative redox shift precedes these markers and leads to...

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Identifiers

PMID: 22539844
DOI: 10.1523/JNEUROSCI.6192-11.2012
PMCID: PMC3376759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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