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Article

Genomic and biochemical approaches in the discovery of mechanisms for selective neuronal vulnerability to oxidative stress

19 Feb 2009

Abstract excerpt

BACKGROUND: Oxidative stress (OS) is an important factor in brain aging and neurodegenerative diseases. Certain neurons in different brain regions exhibit selective vulnerability to OS. Currently little is known about the underlying mechanisms of this selective neuronal vulnerability. The purpose of this study was to identify endogenous factors that predispose vulnerable neurons to OS by employing genomic and...

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PMID: 19228403
DOI: 10.1186/1471-2202-10-12

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