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Article

Nuclear Reprogramming: Kinetics of Cell Cycle and Metabolic Progression as Determinants of Success

18 Apr 2012

Abstract excerpt

Establishment of totipotency after somatic cell nuclear transfer (NT) requires not only reprogramming of gene expression, but also conversion of the cell cycle from quiescence to the precisely timed sequence of embryonic cleavage. Inadequate adaptation of the somatic nucleus to the embryonic cell cycle regime may lay the foundation for NT embryo failure and their reported lower cell counts. We combined bright...

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PMID: 22530006
DOI: 10.1371/journal.pone.0035322

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