Genetic variation in the carbonyl reductase 3 gene confers risk of type 2 diabetes and insulin resistance: a potential regulator of adipogenesis.

doi:10.1007/s00109-012-0898-8

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Article

Genetic variation in the carbonyl reductase 3 gene confers risk of type 2 diabetes and insulin resistance: a potential regulator of adipogenesis.

Journal of molecular medicine (Berlin, Germany) - 1 Jul 2012

Chang Yi-Cheng, Liu Pi-Hua, Tsai Yun-Chih, Chiu Yen-Feng, Shih Shyang-Rong, Ho Low-Tone, Lee Wen-Jane, Lu Chieh-Hua, Quertermous Thomas, Curb J David, Lee Wei-Jei, Lee Po-Chu, He You-Han, Yeh Jih-I, Hwang Juey-Jen, Tsai Shu-Huei, Chuang Lee-Ming

Abstract excerpt

Prostaglandins are potent modulators of insulin sensitivity. We systemically evaluated the association of 61 tag single-nucleotide polymorphisms (SNP) in 14 genes involved in prostaglandin metabolism with type 2 diabetes. Among all genotyped SNPs, rs10483032 in the CBR3 (carbonyl reductase 3) gene, which encodes for an enzyme converting prostaglandin E(2) to prostaglandin F2(α), was associated with type 2...

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PMID: 22527884
DOI: 10.1007/s00109-012-0898-8

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CBR3

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