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Article

CYP2C19 genetics in fatal carisoprodol intoxications.

European journal of clinical pharmacology - 1 Nov 2012

Høiseth Gudrun, Majid Umair, Mørland Jørg, Bramness Jørgen G, Molden Espen

Abstract excerpt

INTRODUCTION: Carisoprodol, a frequently used muscle relaxant, can cause potentially fatal intoxications. Conversion to its active metabolite meprobamate is almost solely mediated by cytochrome P450 2C19 (CYP2C19), and mutations in this enzyme could have significant effects on serum concentrations. The objective of this study was to investigate the role of CYP2C19 genetics in mortalities due to carisoprodol...

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Identifiers

PMID: 22527345
DOI: 10.1007/s00228-012-1278-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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