Article
A combined DPA1~DPB1 amino acid epitope is the primary unit of selection on the HLA-DP heterodimer.
Immunogenetics - 1 Aug 2012
Hollenbach Jill A, Madbouly Abeer, Gragert Loren, Vierra-Green Cynthia, Flesch Susan, Spellman Stephen, Begovich Ann, Noreen Harriet, Trachtenberg Elizabeth, Williams Tom, Yu Neng, Shaw Bronwen, Fleischhauer Katharina, Fernandez-Vina Marcelo, Maiers Martin
Abstract excerpt
Here, we present results for DPA1 and DPB1 four-digit allele-level typing in a large (n = 5,944) sample of unrelated European American stem cell donors previously characterized for other class I and class II loci. Examination of genetic data for both chains of the DP heterodimer in the largest cohort to date, at the amino acid epitope, allele, genotype, and haplotype level, allows new insights into the functional...
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