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Article

Signet ring cell differentiation in mucinous colorectal carcinoma

30 Apr 2007

Abstract excerpt

Approximately 10% of all colorectal carcinomas are mucinous carcinomas, characterized by extracellular mucin. Occasionally, mucin accumulates intracellularly in these tumours, causing signet ring cell differentiation. We hypothesized that signet ring cells arise from a separate genetic pathway. In this study the molecular background of signet ring cell differentiation was investigated by analysing genetic...

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PMID: 17471475
DOI: 10.1002/path.2181

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