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Pathogenic BRCA Variants as Biomarkers for Risk in Prostate Cancer

14 Nov 2021

Abstract excerpt

Studies have demonstrated that men with Prostate Cancer (PCa) harboring BRCA2/BRCA1 genetic aberrations, are more likely to have worse disease and a poorer prognosis. A mutation in BRCA2 is known to confer the highest risk of PCa for men (8.6 fold in men ≤65 years) making BRCA genes a conceivable genomic biomarker for risk in PCa. These genes have attracted a lot of research attention however their role in the...

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PMID: 34830851
DOI: 10.3390/cancers13225697

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