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Article

SP-1 regulation of MMP-9 expression requires Ser586 in the PEST domain.

The Biochemical journal - 15 Jul 2012

Murthy Shubha, Ryan Alan J, Carter A Brent

Abstract excerpt

Rac1, a small GTPase, regulates macrophage MMP (matrix metalloproteinase)-9 in an ERK (extracellular-signal-regulated kinase)- and SP (specificity protein)-1-dependent manner. SP-1 contains a PEST (Pro-Glu-Ser-Thr) domain that may modulate protein stability. We hypothesize that Thr578, Ser586 and...

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Source

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Identifiers

PMID: 22519702
DOI: 10.1042/BJ20120053
PMCID: PMC3663053

Genes

MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22519702-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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