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Article

Association of Spermatogenic Failure with the b2/b3 Partial AZFc Deletion

13 Apr 2012

Abstract excerpt

Infertility affects around 1 in 10 men and in most cases the cause is unknown. The Y chromosome plays an important role in spermatogenesis and specific deletions of this chromosome, the AZF deletions, are associated with spermatogenic failure. Recently partial AZF deletions have been described but their association with spermatogenic failure is unclear. Here we screened a total of 339 men with idiopathic...

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Share to Chromosomal and Genetic Variations
Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Sperm and Testicular Function

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PMID: 22514689
DOI: 10.1371/journal.pone.0034902

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Related research

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Association of Spermatogenic Failure with the b2/b3 Partial AZFc DeletionPMID 22514689Read ↗

Partial deletions in the AZFc region of the Y chromosome occur in men with impaired as well as normal spermatogenesisSemantic proximity Read ↗

The b2/b3 subdeletion shows higher risk of spermatogenic failure and higher frequency of complete AZFc deletion than the gr/gr subdeletion in a Chinese population.Semantic proximity Read ↗

Partial deletions are associated with an increased risk of complete deletion in AZFc: a new insight into the role of partial AZFc deletions in male infertilitySemantic proximity Read ↗

A frequent Y chromosome b2/b3 subdeletion shows strong association with male infertility in Han-Chinese populationSemantic proximity Read ↗

Association of partial AZFc region deletions with spermatogenic impairment and male infertility.Semantic proximity Read ↗

Additional genomic duplications in AZFc underlie the b2/b3 deletion-associated risk of spermatogenic impairment in Han Chinese populationSemantic proximity Read ↗

The Association of Partial Azoospermia Factor C Deletions and Male Infertility in Northwestern ChinaSemantic proximity Read ↗

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Y chromosome variants and male reproductive function.Semantic proximity Read ↗

Y chromosome microdeletions and alterations of spermatogenesis.Semantic proximity Read ↗

Screening for AZF Deletion in a Large Series of Severely Impaired Spermatogenesis PatientsSemantic proximity Read ↗

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