Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes.

doi:10.1002/path.4042

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Article

Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes.

The Journal of pathology - 1 Aug 2012

McBride David J, Etemadmoghadam Dariush, Cooke Susanna L, Alsop Kathryn, George Joshy, Butler Adam, Cho Juok, Galappaththige Danushka, Greenman Chris, Howarth Karen D, Lau King W, Ng Charlotte K, Raine Keiran, Teague Jon, Wedge David C, Cancer Study Group Australian Ovarian, Caubit Xavier, Stratton Michael R, Brenton James D, Campbell Peter J, Futreal P Andrew, Bowtell David Dl

Abstract excerpt

The application of paired-end next generation sequencing approaches has made it possible to systematically characterize rearrangements of the cancer genome to base-pair level. Utilizing this approach, we report the first detailed analysis of ovarian cancer rearrangements, comparing high-grade serous and clear cell cancers, and these histotypes with other solid cancers. Somatic rearrangements were systematically...

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Source

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Identifiers

PMID: 22514011
DOI: 10.1002/path.4042
PMCID: PMC3428857

Genes

BRCA1
BRCA2
TSHZ3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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