Article
Mutations in MITF and PAX3 cause "splashed white" and other white spotting phenotypes in horses.
PLoS genetics - 1 Jan 2012
Hauswirth Regula, Haase Bianca, Blatter Marlis, Brooks Samantha A, Burger Dominik, Drögemüller Cord, Gerber Vincent, Henke Diana, Janda Jozef, Jude Rony, Magdesian K Gary, Matthews Jacqueline M, Poncet Pierre-André, Svansson Vilhjálmur, Tozaki Teruaki, Wilkinson-White Lorna, Penedo M Cecilia T, Rieder Stefan, Leeb Tosso
Abstract excerpt
During fetal development neural-crest-derived melanoblasts migrate across the entire body surface and differentiate into melanocytes, the pigment-producing cells. Alterations in this precisely regulated process can lead to white spotting patterns. White spotting patterns in horses are a complex trait with a large phenotypic variance ranging from minimal white markings up to completely white horses. The "splashed...
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