Article
Genome-wide association analysis reveals QTL and candidate mutations involved in white spotting in cattle.
Genetics, selection, evolution : GSE - 8 Nov 2019
Jivanji Swati, Worth Gemma, Lopdell Thomas J, Yeates Anna, Couldrey Christine, Reynolds Edwardo, Tiplady Kathryn, McNaughton Lorna, Johnson Thomas J J, Davis Stephen R, Harris Bevin, Spelman Richard, Snell Russell G, Garrick Dorian, Littlejohn Mathew D
Abstract excerpt
BACKGROUND: White spotting of the coat is a characteristic trait of various domestic species including cattle and other mammals. It is a hallmark of Holstein-Friesian cattle, and several previous studies have detected genetic loci with major effects for white spotting in animals with Holstein-Friesian ancestry. Here, our aim was to better understand the underlying genetic and molecular mechanisms of white...
Topics
- Animals
- Cattle
- Genome-Wide Association Study
- Microphthalmia-Associated Transcription Factor
- Mutation
- PAX3 Transcription Factor
- Polymorphism, Single Nucleotide
- Proto-Oncogene Proteins c-kit