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Functional Analysis of the Polyketide Synthase Genes in the Filamentous Fungus<i>Gibberella zeae</i>(Anamorph<i>Fusarium graminearum</i>)

1 Nov 2005

Abstract excerpt

Polyketides are a class of secondary metabolites that exhibit a vast diversity of form and function. In fungi, these compounds are produced by large, multidomain enzymes classified as type I polyketide synthases (PKSs). In this study we identified and functionally disrupted 15 PKS genes from the genome of the filamentous fungus Gibberella zeae. Five of these genes are responsible for producing the mycotoxins...

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PMID: 16278459
DOI: 10.1128/ec.4.11.1926-1933.2005

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