Karyotype Evolution on Fluorescent In Situ Hybridization Analysis Is Associated With Short Survival in Patients With Chronic Lymphocytic Leukemia and Is Related to CD49d Expression

Abstract excerpt

TO THE EDITOR: In our 2006 report in the Journal of Clinical Oncology,1 we described the frequency of clonal evolution on fluorescent in situ hybridization (FISH) analysis in a prospective, longitudinal cohort study of 159 patients with previously untreated chronic lymphocytic leukemia (CLL). Clonal evolution on FISH analysis was observed in approximately 25% of patients after follow-up at 5+ years and frequently...

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