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Article

A role for GPx3 in activity of normal and leukemia stem cells

16 Apr 2012

Abstract excerpt

The determinants of normal and leukemic stem cell self-renewal remain poorly characterized. We report that expression of the reactive oxygen species (ROS) scavenger glutathione peroxidase 3 (GPx3) positively correlates with the frequency of leukemia stem cells (LSCs) in Hoxa9+Meis1-induced leukemias. Compared with a leukemia with a low frequency of LSCs, a leukemia with a high frequency of LSCs showed...

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PMID: 22508837
DOI: 10.1084/jem.20102386

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