Article
Human papillomavirus and gene mutations in head and neck squamous carcinomas.
ANZ journal of surgery - 1 May 2012
Friedland Peter, Thomas Anitha, Naran Anupam, Amanuel Benhur, Grieu-Iacopetta Fabienne, Carrello Amerigo, Harnett Gerald, Meyer Christine, Phillips Michael
Abstract excerpt
BACKGROUND: Human papillomavirus (HPV) infection is implicated as an aetiological factor in head and neck squamous carcinomas (HNSCC), especially in the tonsils of the oropharyngeal region. This study investigates the frequency of HPV infection, p16 and p53 tumour profile and mutations in epidermal growth factor receptor (EGFR), Kirsten RNA Associated Rat Sarcoma 2 Virus (KRAS) and B-Raf proto-oncogene...
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