Article
EGFR mutations and human papillomavirus in squamous cell carcinoma of tongue and tonsil.
European journal of cancer (Oxford, England : 1990) - 1 Feb 2007
Na Im Il, Kang Hye Jin, Cho Soo Youn, Koh Jae Soo, Lee Jin Kyung, Lee Byeong Cheol, Lee Guk Haeng, Lee Yong Sik, Yoo Hyung Jun, Ryoo Baek-Yeol, Yang Sung Hyun, Shim Yoon Sang
Abstract excerpt
This study was performed to determine the clinical significance of mutations in the EGFR (epidermal growth factor receptor) along with their association with human papillomavirus (HPV) infections in patients with squamous cell carcinoma of the head and neck (HNSCC). Exons 18-21 of the EGFR tyrosine kinase domain were sequenced and HPV typing was carried out using the HPV DNA chip in tissues obtained from patients...
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