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Article

Mesenchymal-specific deletion of C/EBPβ suppresses pulmonary fibrosis.

The American journal of pathology - 1 Jun 2012

Hu Biao, Wu Zhe, Nakashima Taku, Phan Sem H

Abstract excerpt

The CCAAT/enhancer-binding protein β (C/EBPβ) regulates a variety of factors and cellular responses associated with pulmonary fibrosis. To distinguish its role in the mesenchyme from that in other compartments, the effects of mesenchymal-specific deletion of C/EBPβ on pulmonary fibrosis was examined. Crossing of mice with the floxed C/EBPβ gene with α2(I) collagen enhancer-CreER(T)-bearing mice successfully...

Topics

Animals
Bleomycin
CCAAT-Enhancer-Binding Protein-beta
Cell Differentiation
Cells, Cultured
Gene Deletion
Gene Expression Regulation
Genetic Predisposition to Disease
Mesoderm
Mice
Mice, Knockout

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myofibroblasts

Oligonucleotide Array Sequence Analysis

Pulmonary Fibrosis

Source

Open in PubMed Open full text

Identifiers

PMID: 22503555
DOI: 10.1016/j.ajpath.2012.02.010
PMCID: PMC3378850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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