Article
Suppression of epidermal growth factor receptor (EGFR) expression by small hairpin RNA inhibits the growth of human nonsmall cell lung cancers bearing wild-type and mutant EGFR.
Cancer investigation - 1 Dec 2011
Zhang Shuang, Tian Hongwei, Jiang Qingyuan, Li Li, Ding Yu, Dai Lei, Xiang Yu, Shen Guobo, Cheng Lin, Huang Qiaorong, Liu Yalin, Zhang Xiaomei, Ma Yongping, Zhang Na, Liu Shengyong, Wang Wei, Dai Lixia, Li Yiming, Zhao Xia, Wei Yuquan, Deng Hongxin
Abstract excerpt
In the present study, we have used plasmid-based RNA interference (RNAi) strategy to downregulate the expression of epidermal growth factor receptor (EGFR) in EGFR wild-type (H292) and mutant (H1975) lung tumor models. The targeted knockdown of EGFR by small hairpin RNA not only inhibited growth of H292 xenograft but also inhibited H1975 lung cancer cell and xenograft, which bore L858R/T790M EGFR and was...
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