Article
Epidermal growth factor receptor mutations in patients with non-small cell lung cancer.
Cancer research - 1 Sept 2005
Johnson Bruce E, Jänne Pasi A
Abstract excerpt
A year has passed since mutations of the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) were discovered in patients with non-small cell lung cancer (NSCLC) who had dramatic clinical responses to treatment with gefitinib. Additional laboratory and clinical studies have provided further insight into the biological impact of EGFR mutations in cell culture experiments and in patients with...
Topics
- Carcinoma, Non-Small-Cell Lung
- ErbB Receptors
- Genes, erbB-1
- Humans
- Lung Neoplasms
- Mutation