Article
Maternal methionine supplementation promotes the remediation of axial defects in Axd mouse neural tube mutants.
Teratology - 1 Feb 1992
Essien F B
Abstract excerpt
The Axd (axial defects) mouse model system (Essien et al., Teratology 42:183-194, '90) is characterized by a dominant mutation which causes posterior open neural tube defects (NTD) and a variety of tail anomalies (curly tails, or CT). Repeated backcrosses to BALB/cByJ mice have resulted in a 50%...
Topics
- Animals
- Crosses, Genetic
- Disease Models, Animal
- Embryonic and Fetal Development
- Female
- Gene Expression
- Methionine
- Mice
- Mice, Inbred Strains
- Mice, Mutant Strains
- Mutation
- Neural Tube Defects
- Pregnancy