Maternal methionine supplementation promotes the remediation of axial defects in Axd mouse neural tube mutants.

Abstract excerpt

The Axd (axial defects) mouse model system (Essien et al., Teratology 42:183-194, '90) is characterized by a dominant mutation which causes posterior open neural tube defects (NTD) and a variety of tail anomalies (curly tails, or CT). Repeated backcrosses to BALB/cByJ mice have resulted in a 50% increase in Axd penetrance among neonates of heterozygous matings and loss of a correlation with maternal tail...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Crosses, Genetic
• Share to Disease Models, Animal
• Share to Gene Expression