Article
Expression of a new mutation (Axd) causing axial defects in mice correlates with maternal phenotype and age.
Teratology - 1 Aug 1990
Essien F B, Haviland M B, Naidoff A E
Abstract excerpt
A new autosomal mutation, Axd (axial defects), is described. Axd segregates in a simple Mendelian fashion, and it is dominant with incomplete penetrance and variable expressivity. The phenotype of Axd heterozygotes ranges from a variety of tail anomalies to visibly normal tails. Approximately 12% of neonates from curly-tail (CT) F1 (Axd/+) x F1 (Axd/+) matings exhibit open neural tube defects (NTD) in the...
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