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Article

<emph type="ital">CYP2C19</emph> Genotype and Cardiovascular Events

10 Apr 2012

Abstract excerpt

To the Editor: The recent meta-analysis by Dr Holmes and colleagues concluding that CYP2C19 genotype is not a significant predictor of clinical outcomes in patients treated with clopidogrel contrasts with a previous meta-analysis and a large body of pharmacokinetic and pharmacodynamic evidence, including a genome-wide association study. The authors cite small-study bias and inability to evaluate effect...

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PMID: 22496255
DOI: 10.1001/jama.2012.443

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