Article
A systematic review and critical assessment of 11 discordant meta-analyses on reduced-function CYP2C19 genotype and risk of adverse clinical outcomes in clopidogrel users.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2015
Osnabrugge Ruben L, Head Stuart J, Zijlstra Felix, ten Berg Jurriën M, Hunink Myriam G, Kappetein A Pieter, Janssens A Cecile J W
Abstract excerpt
We systematically investigated how 11 overlapping meta-analyses on the association between CYP2C19 loss-of-function alleles and clinical efficacy of clopidogrel could yield contradictory outcomes. The results of the meta-analyses differed because more recent meta-analyses included more primary studies and some had not included conference abstracts. Conclusions differed because between-study heterogeneity and...
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