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Article

Heritable polymorphism predisposes to high BAALC expression in acute myeloid leukemia.

Proceedings of the National Academy of Sciences of the United States of America - 24 Apr 2012

Eisfeld Ann-Kathrin, Marcucci Guido, Liyanarachchi Sandya, Döhner Konstanze, Schwind Sebastian, Maharry Kati, Leffel Benjamin, Döhner Hartmut, Radmacher Michael D, Bloomfield Clara D, Tanner Stephan M, de la Chapelle Albert

Abstract excerpt

Overexpression of the brain and acute leukemia, cytoplasmic (BAALC) gene is implicated in myeloid leukemogenesis and associated with poor outcome in both acute myeloid leukemia (AML) and acute lymphoblastic leukemia patients. Additionally, high BAALC expression occurs in glioblastoma, melanoma, and childhood gastrointestinal stroma tumors, suggesting an oncogenic role for BAALC. However, the mechanisms underlying...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22493267
DOI: 10.1073/pnas.1203756109
PMCID: PMC3340094

Genes

BAALC
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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