Article
BAALC expression predicts clinical outcome of de novo acute myeloid leukemia patients with normal cytogenetics: a Cancer and Leukemia Group B Study.
Blood - 1 Sept 2003
Baldus Claudia D, Tanner Stephan M, Ruppert Amy S, Whitman Susan P, Archer Kellie J, Marcucci Guido, Caligiuri Michael A, Carroll Andrew J, Vardiman James W, Powell Bayard L, Allen Steven L, Moore Joseph O, Larson Richard A, Kolitz Jonathan E, de la Chapelle Albert, Bloomfield Clara D
Abstract excerpt
Cytogenetic aberrations are important prognostic factors in acute myeloid leukemia (AML). Of adults with de novo AML, 45% lack cytogenetic abnormalities, and identification of predictive molecular markers might improve therapy. We studied the prognostic impact of BAALC (Brain And Acute Leukemia, Cytoplasmic), a novel gene involved in leukemia, in 86 de novo AML patients with normal cytogenetics who were uniformly...
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