Trisomic pregnancy and intermediate CGG repeat length at the FMR1 locus.

doi:10.1093/humrep/des098

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Article

Trisomic pregnancy and intermediate CGG repeat length at the FMR1 locus.

Human reproduction (Oxford, England) - 1 Jul 2012

Kline J, Kinney A, Brown S, Levin B, Oppenheimer K, Warburton D

Abstract excerpt

BACKGROUND: We hypothesized that trisomy arises as a function of the size of the oocyte pool, with risk increased among women with diminished pools. Diminished pools may cause primary ovarian failure, which has been associated with premutation and intermediate CGG repeat length at the Fragile X mental retardation (FMR1) locus. Thus, we hypothesized that the risk of trisomic pregnancy is increased among women with...

Topics

Abortion, Spontaneous
Alleles
Aneuploidy
Case-Control Studies
Chromosome Mapping
Female
Fragile X Mental Retardation Protein
Fragile X Syndrome
Genotype
Humans
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Odds Ratio

Oocytes

Pregnancy

Risk

Trinucleotide Repeat Expansion

Trisomy

Source

Open in PubMed Open full text

Identifiers

PMID: 22493044
DOI: 10.1093/humrep/des098
PMCID: PMC3619969

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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