Article
Increased transmission of intermediate alleles of the FMR1 gene compared with normal alleles among female heterozygotes.
American journal of medical genetics - 17 Jul 2000
Drasinover V, Ehrlich S, Magal N, Taub E, Libman V, Shohat T, Halpern G J, Shohat M
Abstract excerpt
Fragile X syndrome (Fra X) is the most common heritable disease accounting for mental retardation and is caused by an expanded CGG repeat in the first exon of the FMR1gene. Previous studies have shown an increased fertility rate among fragile X carrier mothers and a preponderance of mentally retarded boys among the male offspring. In this study, we examined the transmission of the intermediate allele in the lower...
Topics
- Alleles
- Female
- Fetus
- Fragile X Mental Retardation Protein
- Fragile X Syndrome
- Genetic Testing
- Heterozygote
- Humans
- Nerve Tissue Proteins
- Pregnancy
- Prenatal Diagnosis
- RNA-Binding Proteins
- Trinucleotide Repeat Expansion
- Trinucleotide Repeats