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Latrunculin A Can Improve the Birth Rate of Cloned Mice and Simplify the Nuclear Transfer Protocol by Gently Inhibiting Actin Polymerization1

5 Apr 2012

Abstract excerpt

Although animal cloning is becoming more practicable, there are many abnormalities in cloned embryos, and the success rate of producing live animals by cloning has been low. Here, we focused on the procedure for preventing pseudo-second polar body extrusion from somatic cell nuclear transfer (SCNT)-derived oocytes. Typically, reconstructed oocytes are treated with cytochalasin B (CB), but here latrunculin A...

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PMID: 22492972
DOI: 10.1095/biolreprod.111.098764

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