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RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation

25 Aug 2016

Abstract excerpt

Topoisomerase IIα (TOP2α) is essential for chromosomal condensation and segregation, as well as genomic integrity. Here we report that RNF168, an E3 ligase mutated in the human RIDDLE syndrome, interacts with TOP2α and mediates its ubiquitylation. RNF168 deficiency impairs decatenation activity of TOP2α and promotes mitotic abnormalities and defective chromosomal segregation. Our data also indicate that RNF168...

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PMID: 27558965
DOI: 10.1038/ncomms12638

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