Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of S4D mutant of Leishmania donovani ADF/cofilin impairs flagellum assembly by affecting actin dynamics.

Eukaryotic cell - 1 Jun 2012

Kumar Gaurav, Srivastava Rashmi, Mitra Kalyan, Sahasrabuddhe Amogh A, Gupta Chhitar M

Abstract excerpt

Leishmania, like other eukaryotes, contains large amounts of actin and a number of actin-related and actin binding proteins. Our earlier studies have shown that deletion of the gene corresponding to Leishmania actin-depolymerizing protein (ADF/cofilin) adversely affects flagellum assembly, intracellular trafficking, and cell division. To further analyze this, we have now created ADF/cofilin site-specific point...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actin Depolymerizing Factors
Share to Aspartic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flagella

Share to Intracellular Space

Share to Leishmania donovani

Share to Nucleotides

Share to Polymerization

Share to Transport Vesicles

Source

Open in PubMed Open full text

Identifiers

PMID: 22492507
DOI: 10.1128/EC.00013-12
PMCID: PMC3370458

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of S4D mutant of Leishmania donovani ADF/cofilin impairs flagellum assembly by affecting actin dynamics.PMID 22492507Read ↗

Actin-depolymerizing factor, ADF/cofilin, is essentially required in assembly of Leishmania flagellum.Semantic proximity Read ↗

The kinesin of the flagellum attachment zone in Leishmania is required for cell morphogenesis, cell division and virulence in the mammalian hostSemantic proximity Read ↗

Pathogenic microbes manipulate cofilin activity to subvert actin cytoskeletonSemantic proximity Read ↗

Trafficking activity of myosin XXI is required in assembly ofLeishmaniaflagellumSemantic proximity Read ↗

Leishmania flagellum attachment zone is critical for flagellar pocket shape, development in the sand fly, and pathogenicity in the hostSemantic proximity Read ↗

IFT and BBSome proteins are required for Leishmania mexicana pathogenicity, but flagellar motility is dispensableSemantic proximity Read ↗

Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1.Semantic proximity Read ↗

Role for the flagellum attachment zone in the resolution of cell membrane morphogenesis during <i>Leishmania</i> cell divisionSemantic proximity Read ↗

Dependency relationships between IFT-dependent flagellum elongation and cell morphogenesis in LeishmaniaSemantic proximity Read ↗

Crystal Structures Explain Functional Differences in the Two Actin Depolymerization Factors of the Malaria ParasiteSemantic proximity Read ↗

Unusual actin-binding mechanism and the role of profilin in actin dynamics of trypanosomatid parasitesSemantic proximity Read ↗

Regulation of Apicomplexan Microfilament Dynamics by a Minimal Set of Actin‐Binding ProteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.