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Article

Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1.

Proceedings of the National Academy of Sciences of the United States of America - 14 Jun 2011

Wong Wilson, Skau Colleen T, Marapana Danushka S, Hanssen Eric, Taylor Nicole L, Riglar David T, Zuccala Elizabeth S, Angrisano Fiona, Lewis Heather, Catimel Bruno, Clarke Oliver B, Kershaw Nadia J, Perugini Matthew A, Kovar David R, Gulbis Jacqueline M, Baum Jake

Abstract excerpt

Malaria parasite cell motility is a process that is dependent on the dynamic turnover of parasite-derived actin filaments. Despite its central role, actin's polymerization state is controlled by a set of identifiable regulators that is markedly reduced compared with those of other eukaryotic cells. In Plasmodium falciparum, the most virulent species that affects humans, this minimal repertoire includes two...

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PMID: 21628589
DOI: 10.1073/pnas.1018927108
PMCID: PMC3116436

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