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Article

A reinvestigation of somatic hypermethylation at the PTEN CpG island in cancer cell lines

10 Apr 2012

Abstract excerpt

BACKGROUND: PTEN is an important tumour suppressor gene that is mutated in Cowden syndrome as well as various sporadic cancers. CpG island hypermethylation is another route to tumour suppressor gene inactivation, however, the literature regarding PTEN hypermethylation in cancer is controversial. Furthermore, investigation of the methylation status of the PTEN CpG island is challenging due to sequence homology...

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PMID: 22490388
DOI: 10.1186/1480-9222-14-5

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