Article
Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor.
The Biochemical journal - 1 Jul 2012
Lamberto Ilaria, Qin Haina, Noberini Roberta, Premkumar Lakshmanane, Bourgin Caroline, Riedl Stefan J, Song Jianxing, Pasquale Elena B
Abstract excerpt
The EphA4 receptor tyrosine kinase interacts with ephrin ligands to regulate many processes, ranging from axon guidance and nerve regeneration to cancer malignancy. Thus antagonists that inhibit ephrin binding to EphA4 could be useful for a variety of research and therapeutic applications. In the present study we characterize the binding features of three antagonistic peptides (KYL, APY and VTM) that selectively...
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