Article
Identification of a CACNA2D4 deletion in late onset bipolar disorder patients and implications for the involvement of voltage-dependent calcium channels in psychiatric disorders.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2012
Van Den Bossche Maarten J, Strazisar Mojca, De Bruyne Stephan, Bervoets Chris, Lenaerts An-Sofie, De Zutter Sonia, Nordin Annelie, Norrback Karl-Fredrik, Goossens Dirk, De Rijk Peter, Green Elaine K, Grozeva Detelina, Mendlewicz Julien, Craddock Nick, Sabbe Bernard G, Adolfsson Rolf, Souery Daniel, Del-Favero Jurgen
Abstract excerpt
The GWAS-based association of CACNA1C with bipolar disorder (BPD) is one of the strongest genetic findings to date. CACNA1C belongs to the family of CACN genes encoding voltage-dependent calcium channels (VDCCs). VDCCs are involved in brain circuits and cognitive processes implicated in BPD and schizophrenia (SZ). Recently, it was shown that rare copy number variations (CNVs) are found at an increased frequency...
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