Article
Genome-wide association neural networks identify genes linked to family history of Alzheimer's disease.
Briefings in bioinformatics - 22 Nov 2024
Ghose Upamanyu, Sproviero William, Winchester Laura, Amin Najaf, Zhu Taiyu, Newby Danielle, Ulm Brittany S, Papathanasiou Angeliki, Shi Liu, Liu Qiang, Fernandes Marco, Adams Cassandra, Albukhari Ashwag, Almansouri Majid, Choudhry Hani, van Duijn Cornelia, Nevado-Holgado Alejo
Abstract excerpt
Augmenting traditional genome-wide association studies (GWAS) with advanced machine learning algorithms can allow the detection of novel signals in available cohorts. We introduce "genome-wide association neural networks (GWANN)" a novel approach that uses neural networks (NNs) to perform a gene-level association study with family history of Alzheimer's disease (AD). In UK Biobank, we defined cases (n = 42 110)...
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