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Article

The ARMS2 A69S variant and bilateral advanced age-related macular degeneration.

Retina (Philadelphia, Pa.) - 1 Sept 2012

Schwartz Stephen G, Agarwal Anita, Kovach Jaclyn L, Gallins Paul J, Cade William, Postel Eric A, Wang Gaofeng, Ayala-Haedo Juan, Spencer Kylee M, Haines Jonathan L, Pericak-Vance Margaret A, Scott William K

Abstract excerpt

PURPOSE: To identify genetic associations between specific risk genes and bilateral advanced age-related macular degeneration (AMD) in a retrospective, observational case series of 1,003 patients: 173 patients with geographic atrophy in at least 1 eye and 830 patients with choroidal neovasculariz...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22481475
DOI: 10.1097/IAE.0b013e318240a540
PMCID: PMC4269218

Genes

ARMS2
CFB
CFH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22481475-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The ARMS2 A69S variant and bilateral advanced age-related macular degeneration.PMID 22481475Read ↗

Genetics of Unilateral and Bilateral Age-Related Macular Degeneration Severity Stages.Semantic proximity Read ↗

Association of ARMS2 genotype with bilateral involvement of exudative age-related macular degeneration.Semantic proximity Read ↗

Difference between age-related macular degeneration and polypoidal choroidal vasculopathy in the hereditary contribution of the A69S variant of the age-related maculopathy susceptibility 2 gene (ARMS2).Semantic proximity Read ↗

Risk characteristics of the combined geographic atrophy and choroidal neovascularisation phenotype in age-related macular degeneration.Semantic proximity Read ↗

Comparison of ARMS2/LOC387715 A69S and CFH Y402H risk effect in wet-type age-related macular degeneration: a meta-analysis.Semantic proximity Read ↗

Distribution of risk alleles in patients with age-related macular degeneration.Semantic proximity Read ↗

CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD.Semantic proximity Read ↗

Association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V polymorphisms with retinal angiomatous proliferation compared with typical age-related macular degeneration: a meta-analysis.Semantic proximity Read ↗

ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration.Semantic proximity Read ↗

CFH and ARMS2 variations in age-related macular degeneration, polypoidal choroidal vasculopathy, and retinal angiomatous proliferation.Semantic proximity Read ↗

Complement factor H and the bilaterality of age-related macular degeneration.Semantic proximity Read ↗

Next-generation sequencing analysis of the ARMS2 gene in Turkish exudative age-related macular degeneration patients.Semantic proximity Read ↗

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