Article
Bombyx mori homolog of tumor suppressor p53 is involved in apoptosis-mediated antiviral immunity of B. mori cells infected with nucleopolyhedrovirus.
Developmental and comparative immunology - 1 Jul 2018
Makino Shizuka, Hamajima Rina, Saito Aya, Tomizaki Moe, Iwamoto Asako, Kobayashi Michihiro, Yamada Hayato, Ikeda Motoko
Abstract excerpt
Apoptosis is important in antiviral immunity and affects viral multiplication and pathogenesis. Here, we showed that Bombyx mori cells transiently expressing B. mori homolog of the tumor suppressor p53 (Bm-p53) protein underwent apoptosis accompanied by elevated caspase-3-like protease activity and processing of B. mori Dronc (Bm-Dronc). RNAi-mediated silencing of bm-p53 expression, which significantly diminished...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
