Article
Recent advances in the genetics of the ALS-FTLD complex.
Current neurology and neuroscience reports - 1 Jun 2012
Morris Huw R, Waite Adrian J, Williams Nigel M, Neal James W, Blake Derek J
Abstract excerpt
There is a clinical and pathological overlap between amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). A number of autosomal-dominant genes have been described that primarily cause ALS or FTLD such as progranulin (GRN), valosin-containing protein (VCP), and TAR DNA-Binding Protein (TARDBP), and for each of these conditions there are a small number of cases with both ALS and FTLD....
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