Article
A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk.
International journal of cancer - 15 Aug 2012
Campa Daniele, Butterbach Katja, Slager Susan L, Skibola Christine F, de Sanjosé Silvia, Benavente Yolanda, Becker Nikolaus, Foretova Lenka, Maynadie Marc, Cocco Pierluigi, Staines Anthony, Kaaks Rudolf, Boffetta Paolo, Brennan Paul, Conde Lucia, Bracci Paige M, Caporaso Neil E, Strom Sara S, Camp Nicola J, Cerhan James R, Canzian Federico, Nieters Alexandra
Abstract excerpt
Owing to their role in controlling the efflux of toxic compounds, transporters are central players in the process of detoxification and elimination of xenobiotics, which in turn is related to cancer risk. Among these transporters, ATP-binding cassette B1/multidrug resistance 1 (ABCB1/MDR1), ABCC2/multidrug resistance protein 2 (MRP2) and ABCG2/breast cancer resistance protein (BCRP) affect susceptibility to many...
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