Article
Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes.
European journal of human genetics : EJHG - 1 Oct 2012
Webb Bradley T, Guo An-Yuan, Maher Brion S, Zhao Zhongming, van den Oord Edwin J, Kendler Kenneth S, Riley Brien P, Gillespie Nathan A, Prescott Carol A, Middeldorp Christel M, Willemsen Gonneke, de Geus Eco Jc, Hottenga Jouke-Jan, Boomsma Dorret I, Slagboom Eline P, Wray Naomi R, Montgomery Grant W, Martin Nicholas G, Wright Margie J, Heath Andrew C, Madden Pamela A, Gelernter Joel, Knowles James A, Hamilton Steven P, Weissman Myrna M, Fyer Abby J, Huezo-Diaz Patricia, McGuffin Peter, Farmer Anne, Craig Ian W, Lewis Cathryn, Sham Pak, Crowe Raymond R, Flint Jonathan, Hettema John M
Abstract excerpt
Genetic factors underlying trait neuroticism, reflecting a tendency towards negative affective states, may overlap genetic susceptibility for anxiety disorders and help explain the extensive comorbidity amongst internalizing disorders. Genome-wide linkage (GWL) data from several studies of neuroticism and anxiety disorders have been published, providing an opportunity to test such hypotheses and identify genomic...
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