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Article

Polymorphisms in MTHFR, MS and CBS genes and homocysteine levels in a Pakistani population.

PloS one - 1 Jan 2012

Yakub Mohsin, Moti Naushad, Parveen Siddiqa, Chaudhry Bushra, Azam Iqbal, Iqbal Mohammad Perwaiz

Abstract excerpt

BACKGROUND: Hyperhomocysteinemia (>15 µmol/L) is highly prevalent in South Asian populations including Pakistan. In order to investigate the genetic determinants of this condition, we studied 6 polymorphisms in genes of 3 enzymes--methylenetetrahydrofolate reductase (MTHFR; C677T; A1298C), methionine synthase (MS; A2756G), cystathionine-β-synthase (CBS; T833C/844ins68, G919A) involved in homocysteine metabolism...

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22470444
DOI: 10.1371/journal.pone.0033222
PMCID: PMC3310006

Genes

MTHFR
CBS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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