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Article

Effects of Huanglian-Jie-Du-Tang and its modified formula on the modulation of amyloid-β precursor protein processing in Alzheimer's disease models.

PloS one - 1 Jan 2014

Durairajan Siva Sundara Kumar, Huang Ying-Yu, Yuen Pui-Yee, Chen Lei-Lei, Kwok Ka-Yan, Liu Liang-Feng, Song Ju-Xian, Han Quan-Bin, Xue Lei, Chung Sookja K, Huang Jian-Dong, Baum Larry, Senapati Sanjib, Li Min

Abstract excerpt

Huanglian-Jie-Du-Tang (HLJDT) is a famous traditional Chinese herbal formula that has been widely used clinically to treat cerebral ischemia. Recently, we found that berberine, a major alkaloid compound in HLJDT, reduced amyloid-β (Aβ) accumulation in an Alzheimer's disease (AD) mouse model. In this study, we compared the effects of HLJDT, four single component herbs of HLJDT (Rhizoma coptidis (RC), Radix...

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Identifiers

PMID: 24671102
DOI: 10.1371/journal.pone.0092954
PMCID: PMC3966845

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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